Family Nurse Practitioner Exam

Human papilloma virus (HPV) infection of the larynx is most commonly associated with which condition?

1. Laryngeal neoplasia

2. Esophageal stricture

3. Cervical cancer

4. Metaplasia of esophageal squamous cells

The correct answer is: Laryngeal neoplasia

Human papilloma virus (HPV) infection of the larynx is most commonly associated with laryngeal neoplasia, particularly because HPV is known to play a significant role in the pathogenesis of squamous cell carcinomas in various anatomical sites, including the larynx. The larynx, being part of the upper respiratory tract, can be affected by strains of HPV, particularly HPV types 6 and 11, which are often implicated in benign conditions like recurrent respiratory papillomatosis. However, HPV can also lead to dysplastic changes and the potential development of neoplasia. In contrast, esophageal stricture and metaplasia of esophageal squamous cells are less directly linked to HPV. Esophageal strictures are often the result of gastroesophageal reflux disease or other irritative processes, rather than viral infections. Similarly, metaplasia, such as Barrett's esophagus, is typically caused by chronic acid exposure rather than viral factors. While cervical cancer is extensively associated with HPV infection, it is primarily related to the cervix rather than the larynx, making it less relevant in the context of laryngeal HPV infection. Hence, laryngeal neoplasia is the most