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Which medication is most appropriate for motion sickness in a patient going on a cruise?

  1. Dimenhydrinate (Dramamine)

  2. Metochlopramide (Reglan)

  3. Ondansetron (Zofran)

  4. Scopolamine patch (Transderm Scop)

The correct answer is: Scopolamine patch (Transderm Scop)

The most appropriate medication for motion sickness in a patient going on a cruise is the scopolamine patch (Transderm Scop). This medication is an anticholinergic agent specifically designed for the prevention of nausea and vomiting associated with motion sickness. It is particularly effective because it is administered transdermally, providing a steady release of the medication over time. When applied behind the ear several hours before the anticipated onset of motion, the scopolamine patch works by blocking the vestibular system's signals that cause nausea. This makes it especially beneficial for individuals like those going on a cruise, where prolonged exposure to motion can lead to significant discomfort. Other medications may also address nausea, but do not have the same tailored use or effectiveness specifically for motion sickness. Dimenhydrinate, while commonly used for this purpose, may not be as effective for longer trips because it is taken orally and can cause sedation. Metoclopramide is primarily used for gastric motility issues and not specifically indicated for motion sickness. Ondansetron, although effective for nausea related to chemotherapy or postoperative conditions, is not considered the first line for motion sickness due to its different mechanism of action and efficacy profile in this context. Choosing the scopolamine patch not