Family Nurse Practitioner Exam

Which medication is most likely to cause sexual dysfunction in males?

1. SSRIs

2. ACE inhibitors

3. Amphetamines

4. Atypical antidepressants

The correct answer is: SSRIs

Selective Serotonin Reuptake Inhibitors (SSRIs) are known to cause sexual dysfunction in males as a common side effect. This is primarily due to their mechanism of action, which increases serotonin levels in the brain. While enhancing mood and alleviating symptoms of depression, SSRIs can lead to issues like delayed ejaculation, decreased libido, and erectile dysfunction. The sexual side effects are thought to be related to serotonergic pathways that influence sexual arousal and function. Moreover, these side effects can occur across various SSRIs, albeit with some variability in severity depending on the specific medication and individual patient factors. Considering other options, ACE inhibitors are primarily used for hypertension and heart failure, and while they have side effects, sexual dysfunction is not one of the well-documented ones. Amphetamines, stimulating medications often associated with increased energy and alertness, can sometimes lead to heightened libido. Atypical antidepressants, such as bupropion, are generally associated with fewer sexual side effects compared to SSRIs and can even improve sexual function in some patients. Therefore, SSRIs are the most notable class of medication when it comes to sexual dysfunction in males.