Family Nurse Practitioner Exam

Which of the following describes the correct use of azithromycin in strep throat treatment?

1. It has higher rates of GI adverse effects than erythromycin.

2. It is preferred due to lower side effects and efficacy.

3. It should always be combined with penicillin medications.

4. It is contraindicated in all respiratory infections.

The correct answer is: It is preferred due to lower side effects and efficacy.

Azithromycin is often preferred for the treatment of strep throat, particularly in patients who are allergic to penicillin or those who cannot tolerate it. This preference is due to its effective antibacterial activity against Streptococcus pyogenes, the bacterium most commonly responsible for strep throat, as well as its relatively favorable side effect profile compared to other antibiotics, such as erythromycin. Specifically, azithromycin tends to cause fewer gastrointestinal side effects, making it a more tolerable option for many patients. Its dosing schedule, typically requiring fewer doses over a shorter duration, also adds to patient compliance, which is critical for effective treatment. While it's crucial to recognize that azithromycin is not suitable for everyone—particularly in cases of non-streptococcal infections or certain antibiotic resistances—the overall benefit in terms of side effects and the successful treatment of strep throat makes it a valuable option.