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Which of the following is the most common cause of nongonococcal urethritis?

  1. Escherichia coli

  2. Chlamydia trachomatis

  3. Neisseria gonorrhoeae

  4. Mycoplasma

The correct answer is: Chlamydia trachomatis

The most common cause of nongonococcal urethritis is Chlamydia trachomatis. This organism is a sexually transmitted bacterium that is frequently implicated in cases of urethritis due to its ability to infect the urogenital tract without the presence of gonorrhea, distinguishing it as the primary causative agent in nongonococcal infections. Chlamydia trachomatis can lead to inflammation in the urethra, presenting symptoms such as dysuria and urethral discharge. The prevalence of infections caused by Chlamydia highlights its significance in sexual health and underscores the importance of screening, especially since many cases can be asymptomatic. Understanding the role of Chlamydia trachomatis in non-gonococcal urethritis is crucial for diagnostic accuracy and appropriate management, ensuring that patients receive the correct treatment and reducing the risk of complications associated with untreated infections.